Z-013

Zopiclone-N-oxide solution

100 μg/mL (Methanol with 1% 1 M HCl), ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₇H₁₇ClN₆O₄
• Número de CAS: 43200-96-0
• Peso molecular: 404.81
• MDL number: MFCD00871938
• UNSPSC Code: 41116107
• PubChem Substance ID: 329831596
• NACRES: NA.24

Propiedades

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: (Snap-N-Spike^®)
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL (Methanol with 1% 1 M HCl)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: O=C1N(C2=CC=C(Cl)C=N2)C(OC(N3CC[N+]([O-])(C)CC3)=O)C4=C1N=CC=N4
• InChI: 1S/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
• InChI key: IPTIKKTXLHVRKN-UHFFFAOYSA-N

Descripción

General description

Zopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane^®and ZImovane^®and is used in the treatment of insomnia.

Application

• Enantioselective analysis of zopiclone and its metabolites: A study developed a DLLME-CE method for the enantioselective analysis of zopiclone and its active metabolite, zopiclone-N-oxide, post fungal biotransformation, demonstrating the utility of zopiclone-N-oxide as a reference standard in pharmaceutical metabolite profiling (de Albuquerque et al., 2015).


• Pharmacokinetic studies: An analytical method using liquid chromatography/tandem mass spectrometry was employed for the enantioselective analysis of zopiclone and its metabolites in plasma, showcasing zopiclone-N-oxide′s critical role in bioanalytical studies related to insomnia and GABA receptor modulation (Tonon et al., 2011).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Imovane is a registered trademark of Sanofi-Aventis

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup