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A-003

Supelco

6-Acetylmorphine, 100 μg/mL solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

6-Acetylmorphine solution

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About This Item

Fórmula empírica (notación de Hill):
C19H21NO4
Número de CAS:
2784-73-8
Peso molecular:
327.37
EC Number:
200-835-2
MDL number:
MFCD00467140
UNSPSC Code:
41116107
PubChem Substance ID:
329770565
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®. SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)c35

InChI

1S/C19H21NO4/c1-10(21)23-15-6-4-12-13-9-11-3-5-14(22)17-16(11)19(12,18(15)24-17)7-8-20(13)2/h3-6,12-13,15,18,22H,7-9H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1

InChI key

JJGYGPZNTOPXGV-SSTWWWIQSA-N

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General description

6-Acetylmorphine, also known as 6-monoacetylmorphine or 6-MAM, is an active metabolite of heroin and biomarker for heroin usage. This Certified Spiking Solution® is suitable for use as a starting material in calibrators and controls for GC/MS or LC/MS methods in forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.

Application


  • Drug use monitoring: The utility of 6-acetylmorphine as a specific biomarker in workplace drug testing for identifying illicit heroin use among morphine-positive urine specimens was highlighted, affirming its importance in forensic and clinical toxicology (Vikingsson et al., 2024).

  • Physiological monitoring technology: The detection of 6-acetylmorphine in sweat at the molecular level demonstrates the potential of the wearable SERS sensor in monitoring drug use (Liu et al., 2024).

  • Drug effect attenuation research: A bivalent conjugate vaccine inducing dual immunogenic responses was studied to attenuate the effects of heroin and fentanyl in mice, utilizing 6-acetylmorphine as a component, demonstrating its potential in therapeutic developments (Barrientos et al., 2021).

  • Behavioral toxicology: The determination of drugs of abuse in hair samples using LC-MS/MS, which included 6-acetylmorphine, provided vital data for investigations related to suicide attempts, highlighting its utility in clinical and forensic toxicology (Cardoso et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Referencia del producto
Descripción
Precios

A-009

6-Acetylmorphine, 1.0 mg/mL solution, 1 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-006

6-Acetylmorphine-d3 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-010

6-Acetylmorphine-d3 solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-026

6-Acetylmorphine-d6 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

A-027

6-Acetylmorphine-d6 solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

H-036

Heroin-D9 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

H-037

Heroin-D9 solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

H-038

Heroin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

M-003

Morphine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-006

Morphine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-030

Morphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-085

Morphine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

Morphine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tarek Mahdy et al.
Journal of analytical toxicology, 36(8), 548-559 (2012-08-31)
Heroin is one of the most dangerous abused drugs in the world. Tramadol is an additive recently found at high concentration levels in street heroin seizures in Egypt. This substance could affect the usual analytical method for the detection of
Cai Tie et al.
Journal of mass spectrometry : JMS, 47(11), 1429-1434 (2012-11-14)
With the combination of high separation ability of capillary electrophoresis (CE) and strong identification ability of mass spectrometry (MS), CE/MS is becoming a powerful tool for polar and ionic analytes analysis. Different interfaces have been developed to enhance the sensitivity
Ying-Ying Sun et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 46(12), 1501-1506 (2012-03-02)
The paper reports the establishment of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneous analysis of 11 opiates in hair samples, and the study of presence of opiates in the hair of active heroin addicts. About 20 mg of decontaminated
Kar-Weng Chan et al.
Science & justice : journal of the Forensic Science Society, 52(1), 9-16 (2012-02-14)
Apart from routine analysis of total morphine content required by the criminal justice system, quantification of other major components in illicit heroin has not been considered by the Malaysian enforcement laboratory. In order to quantify various other cutting agents in
M D Raleigh et al.
The Journal of pharmacology and experimental therapeutics, 344(2), 397-406 (2012-12-12)
Morphine conjugate vaccines have effectively reduced behavioral effects of heroin in rodents and primates. To better understand how these effects are mediated, heroin and metabolite distribution studies were performed in rats in the presence and absence of vaccination. In non-vaccinated
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