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934208

Sigma-Aldrich

NanoFabTx™ DBCO Lipid Mix

for synthesis of DBCO-functionalized liposomes

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.28

Quality Level

100

storage temp.

−20°C

Application

NanoFabTx™ DBCO Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of DBCO-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.

This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with DBCO groups using extrusion and microfluidics are also included. The synthesized DBCO-functionalized liposomes enable the conjugation of azide-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of DBCO-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
  • Lipid mix optimized for azide-tagged protein or antibody conjugation and small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the Protocol section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Daxing Liu et al.
Scientific reports, 12(1), 10564-10564 (2022-06-23)
Given our interest in the utility of liposomes for molecular imaging and theranostics, we investigated how coating the outer layer of the liposome affects internalization by breast cancer cell lines in vitro and in breast tumor tissues in vivo. Indeed

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