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765090

Sigma-Aldrich

Polyethylenimine, linear

average Mn 10,000, PDI ≤1.3

Sinónimos:

PEI

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About This Item

Fórmula lineal:
(CH2CH2NH)n
Número de CAS:
9002-98-6
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

mol wt

average Mn 10,000

mp

48-53 °C

PDI

≤1.3

storage temp.

2-8°C

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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General description

Polyethylenimine (linear) is a versatile cationic polymer with a high transfection efficiency. It is used as a gene delivery reagent. It is a non-lipid polycation that can be used to transfect oligonucleotides and plasmid into cells in vitro and in vivo.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
Wiseman JW, et al.
Gene Therapy, 10(19), 1654-1654 (2003)
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou S, et al.
The journal of gene medicine, 2(2), 128-134 (2000)
Bromodomain and extra-terminal (BET) protein inhibitors suppress chondrocyte differentiation and restrain bone growth
Niu N, et al.
The Journal of biological chemistry, 291(52), 26647-26657 (2016)
Marie-Elise Bonnet et al.
Pharmaceutical research, 25(12), 2972-2982 (2008-08-19)
The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for nucleic acid delivery due to
Dae Hee Lee et al.
Biomaterials, 171, 34-45 (2018-04-22)
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative.
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Delivery of Nucleic Acids Using Polymers

This review will focus on the sub-sector of drug delivery concerning the delivery of nucleic acids, with a particular focus on poly(ethyleneimine).

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

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