- Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.
Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.
Organic letters (2009-12-22)
Yohsuke Watanabe, Takashi Yamazaki, Toshio Kubota
PMID20020733
ABSTRACT
The boron aldol reaction of beta-substituted glutaric imides bearing an oxazolidinone-based auxiliary proceeds with excellent diastereoselectivity; switching the tertiary amine employed between i-Pr(2)EtN or Et(3)N affords enantiomeric lactone product.
MATERIALS