SML2925
MESM
≥98% (HPLC)
Synonym(s):
5′-(2-Hydroxyphenyl)-1-methylspiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one, Manganese-Extracting Small Molecule, VU0028386
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About This Item
Empirical Formula (Hill Notation):
C16H13N3O2S
CAS Number:
Molecular Weight:
311.36
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
MESM is a cell penetrant and non-toxic selective manganese ionophore that potently facilitates of manganese export from cells. MESM can be used to rapidly extract and quantify cellular manganese content in a non-lethal and selective MESMER (Manganese-Extracting Small Molecule Estimation Route) assay. MESM does not impacted Fura-2 AM fluorescence.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Kyle J Horning et al.
The Journal of biological chemistry, 295(12), 3875-3890 (2020-02-13)
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one of these chemicals induces rapid
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