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L0879

Sigma-Aldrich

Leu-Leu-Leu

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(s):

Trileucine

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About This Item

Empirical Formula (Hill Notation):
C18H35N3O4
CAS Number:
10329-75-6
Molecular Weight:
357.49
MDL number:
MFCD00038309
UNSPSC Code:
12352202
PubChem Substance ID:
24896267
NACRES:
NA.26

product name

Leu-Leu-Leu, ≥90% (elemental analysis)

Assay

≥90% (elemental analysis)

form

powder

technique(s)

electron microscopy: suitable
mass spectrometry (MS): suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChI key

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Related Categories

Amino Acid Sequence

Leu-Leu-Leu

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hui Ding et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)
Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into
Anna Andrzejewska et al.
Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)
The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of
Hui Ding et al.
Biomaterials, 34(1), 217-225 (2012-10-16)
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as
David Lechuga-Ballesteros et al.
Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge
K L Strauch et al.
Journal of bacteriology, 156(2), 743-751 (1983-11-01)
Pseudorevertants able to use L-leucyl-L-leucyl-L-leucine as a leucine source have been isolated from a Salmonella typhimurium strain carrying stable (nonreverting) mutations in pepN, pepA, and pepB. These strains carry mutations at a locus pto (peptidase T overproducer) tightly linked to
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