95144

Retinol

BioXtra, ≥97.5% (HPLC), ~3100 U/mg

• Synonym(s): Axerophthol, Vitamin A, Vitamin A alcohol, Vitamin A₁, all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
• Empirical Formula (Hill Notation): C₂₀H₃₀O
• CAS Number: 68-26-8
• Molecular Weight: 286.45
• Beilstein: 403040
• EC Number: 200-683-7
• MDL number: MFCD00001552
• UNSPSC Code: 12352205
• eCl@ss: 34058018
• PubChem Substance ID: 57653654
• NACRES: NA.28

Properties

• biological source: synthetic
• product line: BioXtra
• Assay: ≥97.5% (HPLC)
• form: (Powder or Powder with Lumps)
• specific activity: ~3100 U/mg
• shelf life: limited shelf life
• color: faint yellow to very dark yellow
• mp: 56-61 °C; 61-63 °C (lit.)
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1
• InChI: 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
• InChI key: FPIPGXGPPPQFEQ-OVSJKPMPSA-N

Description

General description

Retinol or vitamin A alcohol is the main circulating form of vitamin A.

Application

Retinol has been used:

• as a standard in peak identification and quantification in reverse phase HPLC
• as a standard to estimate the concentration of vitamin A
• to study the inhibitory effect of retinol on murine norovirus (MNV) replication in murine RAW 264.7 cells
• as a component in the reaction mixture for the lecithin:retinol acyltransferase (LRAT) assay

Biochem/physiol Actions

It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid.

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Unit Definition

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H317,H319,H360FD,H413
• Precautionary Statements: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves