Aryl-heteroaryl derivatives as novel wake-promoting agents.

Aryl-heteroaryl derivatives as novel wake-promoting agents.

Chemical biology & drug design (2012-11-01)

Brigitte Lesur, Yin G Lin, Val R Marcy, Lisa D Aimone, John Gruner, Edward R Bacon, Sankar Chatterjee

ABSTRACT

In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.

MATERIALS

Product Number

Brand

Product Description

Y0000635

Modafinil, European Pharmacopoeia (EP) Reference Standard

M6940

Sigma-Aldrich

Modafinil, ≥98% (HPLC)

M-084

Supelco

Modafinil solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

Y0000636

Modafinil for system suitability, European Pharmacopoeia (EP) Reference Standard