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N1892

Supelco

Nadolol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C17H27NO4
CAS Number:
42200-33-9
Molecular Weight:
309.40
EC Number:
255-706-3
MDL number:
MFCD00079476
UNSPSC Code:
41116107
PubChem Substance ID:
329818591
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12

InChI

1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1

InChI key

VWPOSFSPZNDTMJ-UCWKZMIHSA-N

Gene Information

human ... ADRB1(153) , ADRB2(154)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

β-Adrenergic blocker

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ9822
BCCL0909
BCCG6502
BCCC7386
BCBZ8568

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Sarah Maud Fischer et al.
International journal of pharmaceutics, 422(1-2), 52-58 (2011-10-27)
The compatibility of fasted state simulated intestinal fluid (FaSSIF) in drug permeation studies employing the phospholipid vesicle-based permeation assay (PVPA) model was confirmed by a set of different integrity indicators. Neither calcein permeability nor electrical resistance were found significantly changed
Wai Gin Lee et al.
Metabolism: clinical and experimental, 61(11), 1547-1553 (2012-05-09)
Elevated resting energy expenditure (REE) is seen in liver cirrhosis and is associated with reduced transplant-free survival. Non-selective β-blockers reduce REE in acute hypermetabolic conditions. We examined whether non-selective β-blockers reduce REE in patients with stable liver cirrhosis. Twenty-two stable
Sarah Maud Fischer et al.
The Journal of pharmacy and pharmacology, 63(8), 1022-1030 (2011-07-02)
The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle-based permeation assay (PVPA), which excludes other than trans-membrane diffusion pathways. Barrier integrity was monitored both by electrical resistance and permeability
Ling Wang et al.
The Science of the total environment, 426, 289-295 (2012-04-17)
Beta-blockers, prescribed for the treatment of high blood pressure and for long-term use after a heart attack, have been detected in surface and ground waters. This study examines the photochemical fate of three beta-blockers, atenolol, metoprolol, and nadolol. Hydrolysis accounted
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