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  • One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.

One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.

Journal of the American Chemical Society (2014-12-09)
Woon-Yew Siau, Jeffrey W Bode
ABSTRACT

The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoromethylketones yields α-CF3 morpholines and piperazines.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
SnAP Pip Reagent
Sigma-Aldrich
SnAP OA Reagent
Sigma-Aldrich
SnAP DA Reagent
Sigma-Aldrich
SnAP M Reagent, 95%
Sigma-Aldrich
SnAP 3Me-M Reagent