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Homogeneous palladium-catalyzed asymmetric hydrogenation.

Chemical Society reviews (2012-11-10)
Qing-An Chen, Zhi-Shi Ye, Ying Duan, Yong-Gui Zhou
ABSTRACT

The transition metal catalyzed asymmetric hydrogenation of unsaturated compounds arguably presents one of the most attractive methods for the synthesis of chiral compounds. Over the last few decades, Pd has gradually grown up as a new and popular metal catalyst in homogeneous asymmetric hydrogenation the same as traditional Ru, Rh and Ir catalysts. Much progress has been successfully achieved in the asymmetric reduction of imines, enamines, olefins, ketones and heteroarenes. It was also found that palladium catalyzed asymmetric hydrogenation could be used as a key step in tandem reactions to quickly synthesize chiral compounds. This tutorial review intends to offer an overview of recent progress in homogeneous palladium catalyzed asymmetric hydrogenation and should serve as an inspiration for further advances in this area.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Palladium, nanopowder, <25 nm particle size (TEM), ≥99.5%
Sigma-Aldrich
Palladium, foil, thickness 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
Palladium, powder, <75 μm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, powder or granules, 99.99% trace metals basis
Sigma-Aldrich
Palladium, powder, 99.995% trace metals basis
Sigma-Aldrich
Palladium, wire, diam. 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, sponge, 99.9% trace metals basis
Sigma-Aldrich
Palladium, wire, diam. 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
Palladium, foil, not light tested, 50x50mm, thickness 0.03mm, as rolled, 99.95%
Palladium, foil, light tested, 50x50mm, thickness 0.075mm, as rolled, 99.95%
Palladium, foil, not light tested, 25x25mm, thickness 0.0125mm, 99.95%
Palladium, foil, not light tested, 100x100mm, thickness 0.005mm, 99.95%
Palladium, foil, not light tested, 150x150mm, thickness 0.025mm, as rolled, 99.95%
Palladium, foil, not light tested, 50x50mm, thickness 0.005mm, 99.95%
Palladium, rod, 100mm, diameter 2.0mm, 99.95%
Palladium, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.95%
Palladium, foil, not light tested, 150x150mm, thickness 0.03mm, as rolled, 99.95%
Palladium, foil, light tested, 25x25mm, thickness 0.03mm, as rolled, 99.95%
Palladium, rod, 25mm, diameter 6.0mm, 99.95%
Palladium, wire reel, 1m, diameter 0.05mm, as drawn, 99.9%
Palladium, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.99+%
Palladium, wire reel, 0.5m, diameter 0.125mm, hard, 99.95%
Palladium, foil, not light tested, 100x100mm, thickness 0.006mm, 99.95%
Palladium, wire reel, 2m, diameter 0.25mm, hard, 99.95%
Palladium, microfoil, disks, 25mm, thinness 0.5μm, specific density 303.4μg/cm2, permanent mylar 3.5μm support, 99.99%
Palladium, foil, not light tested, 50x50mm, thickness 0.0025mm, 99.95%