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  • Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles.

Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles.

Chemical Society reviews (2011-04-30)
Pazhamalai Anbarasan, Thomas Schareina, Matthias Beller
ABSTRACT

The palladium-catalyzed cyanation of Ar-X (X = I, Br, Cl, OTf, and H) allows for an efficient access towards benzonitriles. After its discovery in 1973 and following significant improvements in recent decades, this methodology has become nowadays the most popular for preparation of substituted aromatic nitriles. In this critical review, we summarize the important developments in this area from 2000 until 2010 (151 references).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Palladium, nanopowder, <25 nm particle size (TEM), ≥99.5%
Sigma-Aldrich
Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
Sigma-Aldrich
Palladium, wire, diam. 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.5 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, powder, <75 μm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, powder or granules, 99.99% trace metals basis
Sigma-Aldrich
Palladium, powder, 99.995% trace metals basis
Sigma-Aldrich
Palladium, sponge, 99.9% trace metals basis
Sigma-Aldrich
Palladium, wire, diam. 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 1.0 mm, 99.9% trace metals basis
Sigma-Aldrich
Palladium, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
Palladium, powder, <1 μm, ≥99.9% trace metals basis
Palladium, foil, light tested, 25x25mm, thickness 0.004mm, 99.95%
Palladium, foil, not light tested, 100x100mm, thickness 0.025mm, as rolled, 99.99+%
Palladium, foil, not light tested, 25x25mm, thickness 0.006mm, 99.95%
Palladium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%
Palladium, foil, not light tested, 25x25mm, thickness 0.00075mm, permanent polyester support, 99.75%
Palladium, foil, 8mm disks, thickness 0.006mm, 99.95%
Palladium, foil, 8mm disks, thickness 0.025mm, as rolled, 99.95%
Palladium, foil, not light tested, 100x100mm, thickness 0.006mm, 99.95%
Palladium, wire reel, 2m, diameter 0.25mm, hard, 99.95%
Palladium, microfoil, disks, 25mm, thinness 0.5μm, specific density 303.4μg/cm2, permanent mylar 3.5μm support, 99.99%
Palladium, foil, not light tested, 50x50mm, thickness 0.0025mm, 99.95%
Palladium, wire reel, 1m, diameter 0.125mm, hard, 99.95%
Palladium, rod, 50mm, diameter 2.0mm, 99.95%
Palladium, wire reel, 2m, diameter 0.25mm, as drawn, 99.99+%
Palladium, wire reel, 0.5m, diameter 1.0mm, hard, 99.95%
Palladium, microfoil, disks, 50mm, thinness 0.05μm, specific density 63.6μg/cm2, permanent mylar 3.5μm support, 99.99%
Palladium, microfoil, disks, 10mm, thinness 0.1μm, specific density 119.2μg/cm2, permanent mylar 3.5μm support, 99.99%