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  • The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial.

The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial.

The American journal of tropical medicine and hygiene (2013-09-05)
Meron Haile, Zerihun Tadesse, Sintayehu Gebreselassie, Berhan Ayele, Teshome Gebre, Sun N Yu, Nicole E Stoller, Bruce D Gaynor, Travis C Porco, Paul M Emerson, Thomas M Lietman, Jeremy D Keenan
ABSTRACT

Latrine use has been promoted as a component of an integrated strategy for trachoma control. As part of a randomized trial in Ethiopia, 12 communities received a mass azithromycin distribution followed by a latrine promotion intervention. A random sample of children ages 0-9 years in each community was monitored longitudinally for ocular chlamydia. After latrine construction ended, those communities with a higher proportion of households using latrines were more likely to experience a reduction in the prevalence of ocular chlamydia. Specifically, for each 10% increase in latrine use, there was a 2.0% decrease (95% confidence interval = 0.2-3.9% decrease) in the community prevalence of ocular chlamydia over the subsequent year (P = 0.04).

MATERIALS
Product Number
Brand
Product Description

Azithromycin for system suitability, European Pharmacopoeia (EP) Reference Standard
Azithromycin, European Pharmacopoeia (EP) Reference Standard
Azithromycin for peak identification, European Pharmacopoeia (EP) Reference Standard
Supelco
Azithromycin, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Azithromycin dihydrate, ≥98% (HPLC)
Sigma-Aldrich
Azithromycin