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  • The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial.

The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial.

The American journal of tropical medicine and hygiene (2013-09-05)
Meron Haile, Zerihun Tadesse, Sintayehu Gebreselassie, Berhan Ayele, Teshome Gebre, Sun N Yu, Nicole E Stoller, Bruce D Gaynor, Travis C Porco, Paul M Emerson, Thomas M Lietman, Jeremy D Keenan
ABSTRACT

Latrine use has been promoted as a component of an integrated strategy for trachoma control. As part of a randomized trial in Ethiopia, 12 communities received a mass azithromycin distribution followed by a latrine promotion intervention. A random sample of children ages 0-9 years in each community was monitored longitudinally for ocular chlamydia. After latrine construction ended, those communities with a higher proportion of households using latrines were more likely to experience a reduction in the prevalence of ocular chlamydia. Specifically, for each 10% increase in latrine use, there was a 2.0% decrease (95% confidence interval = 0.2-3.9% decrease) in the community prevalence of ocular chlamydia over the subsequent year (P = 0.04).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Azithromycin dihydrate, ≥98% (HPLC)
Sigma-Aldrich
Azithromycin
Supelco
Azithromycin, Pharmaceutical Secondary Standard; Certified Reference Material
Azithromycin, European Pharmacopoeia (EP) Reference Standard
Azithromycin for system suitability, European Pharmacopoeia (EP) Reference Standard
Azithromycin for peak identification, European Pharmacopoeia (EP) Reference Standard