Skip to Content
Merck
  • Hydrolysis of single linkage in long DNA using oligonucleotide-multiphosphonate conjugates and Ce IV/EDTA.

Hydrolysis of single linkage in long DNA using oligonucleotide-multiphosphonate conjugates and Ce IV/EDTA.

Nucleic acids symposium series (2004) (2008-09-09)
Yuta Suzuki, Tuomas Lönnberg, Makoto Komiyama
PMID18776412
ABSTRACT

Only one phosphodiester linkage in long DNA was hydrolyzed simply by using two components: oligonucleotide-multiphosphonate conjugates ("gapmers") and Ce(IV)/EDTA (Fig. 1).

MATERIALS
Product Number
Brand
Product Description
72568
Sigma-Aldrich
Nitrilotri(methylphosphonic acid), ≥95% (T)