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Sphingosylphosphorylcholine in cancer progress.

International journal of clinical and experimental medicine (2015-11-10)
Hong-Wei Yue, Qing-Chuan Jing, Ping-Ping Liu, Jing Liu, Wen-Jing Li, Jing Zhao
ABSTRACT

Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an extracellular agent through G protein coupled receptors (GPCRs). Because of elevated levels of SPC in malicious ascites of patients with cancer, the role of SPC in tumor progression has prompted wide interest. The factor was reported to affect the proliferation and/or migration of many cancer cells, including pancreatic cancer cells, epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells, melanoma cells, and human leukemia cells. This review covers current knowledge of the role of SPC in tumor.

MATERIALS
Product Number
Brand
Product Description

Avanti
Lyso SM-d7, Avanti Research - A Croda Brand 860639P, powder
Avanti
Lyso SM (d17:1), Avanti Research - A Croda Brand 860656P, powder