S8442

SU 5416

≥98% (HPLC), powder, neuronal nitric oxide synthase inhibitor

• Synonym(s): 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
• Empirical Formula (Hill Notation): C₁₅H₁₄N₂O
• CAS Number: 204005-46-9
• Molecular Weight: 238.28
• MDL number: MFCD01940922
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278606
• NACRES: NA.77

Properties

• product name: SU 5416, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to yellow-orange
• mp: 221-222 °C
• solubility: DMSO: 20 mg/mL, clear (warmed); H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
• InChI: 1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
• InChI key: WUWDLXZGHZSWQZ-XYOKQWHBSA-N
• Gene Information: human ... EGFR(1956) , FLT1(2321) , IGFBP1(3484) , IL2(3558) , KDR(3791) , PDGFRB(5159) ; mouse ... Flt1(14254) , Kdr(16542)

Description

General description

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis. SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection.

Application

SU 5416 has been used to treat HUVEC cells before the tube formation assay to assess its impact on the network generated from tube formation. to induce pulmonary hypertension (PH) in mice to serve as an experimental model

Biochem/physiol Actions

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.¹ It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.²

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves