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H0396

Sigma-Aldrich

Hydrocortisone-Water Soluble

BioReagent, suitable for cell culture

Synonym(s):

Cyclodextrin-encapsulated hydrocortisone

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About This Item

MDL number:
MFCD00011654
UNSPSC Code:
12352209
PubChem Substance ID:
24895401
NACRES:
NA.77

biological source

plant (wild yam)

product line

BioReagent

form

crystalline

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 400 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

General description

Hydrocortisone has the potential to induce the formation of blood-brain barrier properties in serum-free culture media. It is recommended for use in epithelial and endothelial adherent cell culture applications.

Application

Hydrocortisone-Water Soluble has been used as a supplement in Dulbecco′s modified Eagle′s medium (DMEM)/high glucose medium to culture mammary alveolar (MAC-T) cells. It has also been used to study its effect on cation absorption by semicircular canal duct epithelium via epithelial sodium channel.

Packaging

Package size based on hydrocortisone

related product

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Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360Df

Hazard Classifications

Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P H Wirtz et al.
Heart (British Cardiac Society), 90(8), 853-858 (2004-07-16)
To investigate whether stimulated monocyte cytokine release and its inhibition by glucocorticoids differs between men and women. In vitro monocyte interleukin 6 (IL-6) and tumour necrosis factor alpha (TNFalpha) release after lipopolysaccharide stimulation were assessed with and without co-incubation with
Felipe Perozzo Daltoe et al.
Brazilian oral research, 34, e033-e033 (2020-04-09)
The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype. keratinocytes from human oral mucosa were sorted based on
Alexander Kanitz et al.
PloS one, 7(11), e49568-e49568 (2012-11-21)
Vascular endothelial growth factor A (VEGFA) plays a key role in the angiogenesis of human skin. Elevated levels of VEGFA are associated with several pathological conditions, including chronic inflammatory skin diseases and several types of skin cancer. In particular, squamous
Yohan Choi et al.
Biology of reproduction, 81(6), 1122-1130 (2009-07-31)
Calcium ions have been implicated in the establishment and maintenance of pregnancy, but the regulatory mechanisms of calcium ions in the uterine endometrium and conceptus are not well understood in pigs. Recently, we showed that TRPV6, a calcium ion channel
Yohan Choi et al.
Asian-Australasian journal of animal sciences, 25(1), 44-51 (2012-01-01)
Calcium ions play an important role in the establishment and maintenance of pregnancy, but molecular and cellular regulatory mechanisms of calcium ion action in the uterine endometrium are not fully understood in pigs. Previously, we have shown that calcium regulatory
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