506170
p53-Snail binding Inhibitor, GN25
The p53-Snail binding Inhibitor, GN25 controls the biological activity of p53-Snail. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
p53-Snail binding Inhibitor, GN25, GN25
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About This Item
Empirical Formula (Hill Notation):
C15H14O6S
Molecular Weight:
322.33
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
A cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lee, S., et al. 2010. Oncogene29, 4576.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Ting-Yu Chen et al.
Cell death and differentiation, 28(6), 1865-1879 (2021-01-20)
The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the DNA-PK-p53 cascade induced primary cilia formation (ciliogenesis), thus maintaining the
Yu-Ying Chao et al.
Journal of cellular physiology, 237(12), 4487-4503 (2022-10-18)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of its late diagnosis and chemoresistance. Primary cilia, the cellular antennae, are observed in most human cells to maintain development and differentiation. Primary cilia are gradually lost during
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