20-265
Dithiothreitol, 1M
Synonym(s):
2,3-Butanediol, 1,4-dimercapto-, Cleland′s reagent, Sputolysin
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
Application
Dithiothreitol, 1M may be used as a reducing agent in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) loading buffer. It may also be used as a reagent in saliva sterilization.
Biochem/physiol Actions
Dithiothreitol (DTT), also known as Cleland′s reagent, is a reducing agent containing two thiol functional groups. It serves as a protective regent for thiol groups in protein chemistry studies. DTT is used in chemical peptide synthesis for reducing disulfide bonds in various substrates such as glutathione, proteins, and other macromolecules. It is also used as a mucolytic agent during sputum processing.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
A Novel Dental Caries Model Replacing, Refining, and Reducing Animal Sacrifice
Applied Sciences, 11(15), 7141-7141 (2021)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 99, 1022-1032 (2018-01-09)
Cholestasis is a disorder characterized by impaired bile flow and accumulation of cytotoxic bile acids in the liver. On the other hand, oxidative stress and its deleterious consequences seem to have a significant role in cholestasis-induced organ injury. Hence, antioxidants
Viruses, 12(12) (2020-12-11)
Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore
Thorax, 57(8), 667-671 (2002-08-01)
Sputum analysis is used increasingly to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis. However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum
Journal of inorganic biochemistry, 84(1-2), 77-88 (2001-05-02)
D,L-Dithiothreitol (DTT), known also as Cleland reagent, is a thiol group protectant, used commonly in peptide and protein chemistry. Therefore, it is often added at high concentrations in preparations of proteins relevant to heavy metal biochemistry. The coordination of five
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service