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  • Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family.

Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family.

Proceedings of the National Academy of Sciences of the United States of America (1985-05-01)
E Solomon, L R Hiorns, N Spurr, M Kurkinen, D Barlow, B L Hogan, R Dalgleish
PMID2987919
ABSTRACT

The human type II collagen gene, COL2A1, has been assigned to chromosome 12, the type III gene, COL3A1, to chromosome 2, and one of the type IV genes, COL4A1, to chromosome 13. These assignments were made by using cloned genes as probes on Southern blots of DNA from a panel of mouse/human somatic cell hybrids. The two genes of type I collagen, COL1A1 and COL2A1, have been mapped previously to chromosomes 17 and 7, respectively. This family of conserved genes seems therefore to be dispersed throughout the genome.