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  • The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization.

The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization.

Cytogenetics and cell genetics (1996-01-01)
M Egashira, D Kitamura, T Watanabe, N Niikawa
PMID8978766
ABSTRACT

The human HS1 gene (HCLS1, hematopoietic cell-specific Lyn substrate 1) expressed in human hematopoietic cells encodes a major substrate of protein-tyrosine kinase, p75HS1. This intracellular protein is involved in the signal transduction pathways that initiate at the antigen receptors of both B and T lymphocytes. Fluorescence in situ hybridization using a 2.0-kb cDNA and an 8.0-kb genomic DNA clone of HCLS1 as probes revealed that the gene maps to 3q13.