- Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten.
Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten.
Archives of pharmacal research (2001-03-10)
Y N Han, Y Choo, Y C Lee, Y I Moon, S D Kim, J W Choi
PMID11235812
ABSTRACT
Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.
MATERIALS