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  • Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.

Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis.

The Journal of pediatrics (2012-01-17)
Bita Arabshahi, Robert A Silverman, Olcay Y Jones, Lisa G Rider
ABSTRACT

We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sodium thiosulfate pentahydrate, 99.999% trace metals basis
Sigma-Aldrich
Sodium thiosulfate pentahydrate, BioXtra, ≥99.5%
Sigma-Aldrich
Sodium thiosulfate pentahydrate, ACS reagent, ≥99.5%
Sigma-Aldrich
Sodium thiosulfate pentahydrate, ReagentPlus®, ≥99.5%
Sigma-Aldrich
Sodium thiosulfate, ≥99.99% trace metals basis
Sigma-Aldrich
Sodium thiosulfate, purum p.a., anhydrous, ≥98.0% (RT)
Sigma-Aldrich
Sodium thiosulfate, ReagentPlus®, 99%