Skip to Content
Merck
  • An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.

An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.

Organic letters (2001-03-22)
S Liras, J E Davoren, J Bordner
ABSTRACT

[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.