- Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters (2009-10-16)
Yasuhiro Horita, Takemasa Takii, Taku Chiba, Ryuji Kuroishi, Yasuhiro Maeda, Yukihisa Kurono, Emi Inagaki, Kenji Nishimura, Yoshifumi Yamamoto, Chiyoji Abe, Masami Mori, Kikuo Onozaki
PMID19828313
ABSTRACT
A series of sugar derivatives (1-13) were synthesized and evaluated for antibacterial activity against Mycobacteriumtuberculosis (MTB), especially multi-drug resistant (MDR) MTB, and the structure-activity relationships of these compounds were studied. The results showed that the compound OCT313 (2-acetamido-2deoxy-beta-D-glucopyranosyl N,N-dimethyldithiocarbamate) (4) exhibited significant in vitro bactericidal activity, and that the dithiocarbamate group at C-1 position of the glucopyranoside ring was requisite for the antibacterial activity.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Rifampicin, suitable for plant cell culture, BioReagent, ≥95% (HPLC), powder or crystals