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SBR00034

Sigma-Aldrich

13C-Short Chain Fatty Acids Plasma Mixture

Suitable for mass spectrometry

Synonym(s):

Plasma, SCFA, Sodium acetate-13C2, Sodium butyrate-13C4, Sodium propionate-13C3

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Quality Level

100

lipid type

saturated FAs

storage temp.

−20°C

General description

Short chain fatty acids (SCFAs) are saturated fatty acids with less than 6 carbons. SCFAs are produced in the gut by microbial fermentation of dietary fibers. The most important and researched SCFAs are Acetate (Ac), propionate (Pr) and butyrate (Bu). SCFAs are predominantly found in the colon and cross the intestinal epithelium to the blood stream. SCFAs were found to be beneficial and effective in prevention of obesity, Non-alcoholic fatty liver disease and insulin resistance.
The concentration of SCFAs in Plasma is varied from subject to subject in dependence to the experiment parameters. The Average concentration for Acetate, Propionate and Butyrate 125, 35, 17μM respectively.

13C-SCFAs can serve in various applications:
  • spiking the mixture to track sample preparation errors.
  • QC sample, to exclude run to run variations and to normalize the runs.
  • Calibration curve to quantify SCFAs in Plasma samples.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Emanuel E Canfora et al.
Nature reviews. Endocrinology, 15(5), 261-273 (2019-01-24)
Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible
J H Cummings et al.
Gut, 28(10), 1221-1227 (1987-10-01)
Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral
Ara Koh et al.
Cell, 165(6), 1332-1345 (2016-06-04)
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially
Tara M Henagan et al.
British journal of pharmacology, 172(11), 2782-2798 (2015-01-07)
Sodium butyrate (NaB), an epigenetic modifier, is effective in promoting insulin sensitivity. The specific genomic loci and mechanisms underlying epigenetically induced obesity and insulin resistance and the targets of NaB are not fully understood. The anti-diabetic and anti-obesity effects of

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