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D4036

Sigma-Aldrich

Dynorphin A Porcine Fragment 1-9

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C52H84N18O11
CAS Number:
77259-54-2
Molecular Weight:
1137.34
MDL number:
MFCD00076360
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

UniProt accession no.

P01214

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

Gene Information

pig ... PDYN(445529)

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Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg

Biochem/physiol Actions

Potent κ-agonist

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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M G Gillan et al.
Journal of neurochemistry, 45(4), 1034-1042 (1985-10-01)
Following incubation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25 degrees C and at 0 degrees C. Bestatin
L Miller et al.
European journal of pharmacology, 116(1-2), 159-163 (1985-10-08)
The inhibitory action of dynorphin-(1-9) on the electrically stimulated mouse vas deferens was seen to be antagonised by the delta-selective opioid antagonist ICI 174864. The observed delta-receptor mediated responses were partially, but not totally, prevented by peptidase inhibitors which protect
M Maruyama et al.
Brain research, 401(1), 14-22 (1987-01-13)
This paper describes the binding properties of [3H]peptidergic opioid ligands to binding sites solubilized from rat brain membranes by the treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. The highest amount of the specific binding of [3H]-[D-Ala2-, Met5]enkephalinamide was
P Slater et al.
Neuropeptides, 8(1), 71-76 (1986-07-01)
The autoradiographic distribution of kappa opioid binding sites was evaluated in sections of monkey brain using the selective ligand [3H]dynorphin1-9. Kappa receptors were highly concentrated in the deep layers of the cerebral cortex, the substantia nigra, the hippocampus and the
D Pasotti et al.
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques, 15(2), 71-81 (1993-03-01)
Some neuropeptides may influence various functions of immunocompetent cells. Endogenous opioids have been implicated in the correlation of the immune, endocrine and nervous system. The object of our study was to evaluate the effects induced by some agonist and antagonist
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