CASP4
caspase 4, apoptosis-related cysteine peptidase
Synonyms:
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Species:
Human CASP4 (837), Mouse Casp4 (12363), Rat Casp4 (114555), dog CASP4 (403724), naked mole-rat Casp4 (101700797), domestic guinea pig Casp4 (100731032), cow CASP4 (338039)
UniProtKB ID:
Gene ID:
- Human(837) Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
- Mouse(12363) caspase 4, apoptosis-related cysteine peptidase
- Rat(114555) caspase 4, apoptosis-related cysteine peptidase
- dog(403724) caspase 4, apoptosis-related cysteine peptidase
- naked mole-rat(101700797) caspase 4, apoptosis-related cysteine peptidase
- domestic guinea pig(100731032) caspase 4, apoptosis-related cysteine peptidase
- cow(338039) caspase 4, apoptosis-related cysteine peptidase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CASP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Caspase-4 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Caspase-13 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Caspase 11 antibody produced in rat, clone 17D9, purified from hybridoma cell culture,
Species Reactivity
mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Caspase-4, clone 17D9 Antibody, clone 17D9, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Proteins
Product Number
Description
Species
esiRNA
Small Molecule - Substrate
Product Number
Description
Species
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder,
Species
rat, mouse, human