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Key Documents

50165-U

Nucleosil® C18 HPLC Column

5 μm particle size, L × I.D. 12.5 cm × 4 mm

Synonym(s):

C18 reversed-phase HPLC column

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About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

Agency

suitable for USP L1

Quality Level

product line

Nucleosil®

feature

endcapped

manufacturer/tradename

Nucleosil®

extent of labeling

15% Carbon loading

parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

technique(s)

HPLC: suitable

L × I.D.

12.5 cm × 4 mm

surface area

350 m2/g

matrix

octadecyl

matrix active group

C18 (octadecyl) phase

particle size

5 μm

pore size

100 Å

separation technique

reversed phase

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Application


  • Quantification and Validation of Stability-Indicating RP-HPLC Method for Efavirenz: Demonstrates the utility of Nucleosil® C18 HPLC Column in pharmaceutical analysis, particularly in quality control and stability testing of Efavirenz, ensuring compliance with regulatory standards (Gurumukhi VC, Bari SB, 2022).

  • Development of new method for simultaneous analysis of piracetam and levetiracetam: This study uses the Nucleosil® C18 column to develop robust methods for analyzing neurological medications in pharmaceuticals and biological fluids, contributing to drug stability studies (Siddiqui FA et al., 2014).

  • HPLC method for determination of biologically active epoxy-transformers of treosulfan: The column′s application in plasma analysis highlights its role in pharmacokinetic studies, offering precise measurements critical for dosing and therapeutic monitoring (Główka FK et al., 2012).

  • HPLC analysis of mitoxantrone in mouse plasma and tissues: Illustrates the column′s effectiveness in a pharmacokinetic study, underscoring its importance in the preclinical evaluation of cancer therapies (An G, Morris ME, 2010).

  • Development and validation of an HPLC method for vancomycin: This application in a pharmacokinetic study highlights the column′s critical role in the development and validation of methods for antibiotic analysis, ensuring therapeutic efficacy and safety (Jesús Valle MJ et al., 2008).

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Legal Information

Nucleosil is a registered trademark of Macherey-Nagel GmbH & Co. KG

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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