SRP8026
Annexin V human
recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
Synonym(s):
Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
tag
GST tagged
Assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~52 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
activity assay: suitable
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ANXA5(308)
General description
Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.
Application
Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).
Biochem/physiol Actions
Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.
Physical form
Lyophilized from PBS, pH 7.4.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Recombinant human annexin V fused to a GST-tag.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Shanyue Wang et al.
International immunopharmacology, 84, 106513-106513 (2020-04-25)
Ischemia-reperfusion (I/R) injury causes cardiac dysfunction through several mechanisms including oxidative stress and pro-inflammation. Eleutheroside E (EE) has protective effects in ischemia tissue and anti-inflammatory action. However, the effect of EE on I/R-injured cardiomyocytes is unknown. In this study, we
Zhiqiang Wei et al.
Chinese medicine, 15, 12-12 (2020-02-07)
Osteoarthritis (OA) is a metabolic disorder and able to be relieved by traditional Chinese medicines. However, the effect of Ligusticum wallichii on OA is unknown. Cytokine IL-1β and L. wallichii extracts were used to stimulate the primary mouse chondrocytes. MTT
Lei Huang et al.
Oxidative medicine and cellular longevity, 2020, 4921562-4921562 (2020-08-28)
Neuroinflammation plays an important pathological role in experimental surgical brain injury (SBI). Apoptotic associated with phosphatidylserine (PS) externalization promotes anti-inflammatory mediator TGF-β1 release. In the present study, we investigated the anti-neuroinflammation effect of PS liposome or isoflurane pretreatment via PS/CD36/TGF-β1
Jesse D Gelles et al.
Cell death & disease, 7(12), e2493-e2493 (2016-12-03)
Quantitative and kinetic analyses of apoptotic cell death are integral components of exploring cell biology, measuring cellular stress responses, and performing high-throughput genomic/RNAi/drug screens. Here, we present a detailed method that integrates robust kinetic real-time high-content imaging with Annexin V
Marielle E Yohe et al.
Science translational medicine, 10(448) (2018-07-06)
The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is
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