14690

Bis(cyclohexanone)oxaldihydrazone

for spectrophotometric det. of Cu, ≥99.0%

• Synonym(s): Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
• Empirical Formula (Hill Notation): C₁₄H₂₂N₄O₂
• CAS Number: 370-81-0
• Molecular Weight: 278.35
• Beilstein: 2388004
• EC Number: 206-729-2
• MDL number: MFCD00001659
• UNSPSC Code: 41116105
• PubChem Substance ID: 329750579
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥99.0% (N); ≥99.0%
• form: powder
• quality: for spectrophotometric det. of Cu
• technique(s): UV/Vis spectroscopy: suitable
• mp: 210-214 °C (lit.); 210-214 °C
• SMILES string: O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
• InChI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
• InChI key: DSRJIHMZAQEUJV-UHFFFAOYSA-N

Description

General description

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) is a physically unstable compound and is a well-known neurotoxic agent.

Application

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) was used for toxic demyelination in the central nervous system in order to investigate the pathobiology of remyelination in the corpus callosum, so as to study the human demyelinating diseases such as multiple sclerosis. It was also used a model to study components of neuroinflammation.

Other Notes

For the spectrophotometric determination of Cu(II)

In the presence of a copper salt, this ligand catalyzes Ullmann-type C-N bond forming reactions under mild, aqueous conditions.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves