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Merck
  • Determination of eight pharmaceuticals in an aqueous sample using automated derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry.

Determination of eight pharmaceuticals in an aqueous sample using automated derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry.

Talanta (2015-02-24)
Siming Huang, Fang Zhu, Ruifen Jiang, Shichun Zhou, Derong Zhu, Hong Liu, Gangfeng Ouyang
摘要

An automated aqueous derivatization solid-phase microextraction (SPME) coupled with a gas chromatography/mass spectrometry (GC/MS) method was developed for simultaneous determination of eight pharmaceuticals in water samples. Dimethyl sulfate and tetrabutylammonium hydrogen sulfate were selected as derivatization and activation reagents for the esterification reaction. An experimental design approach, central composition design (CCD), was employed to investigate and optimize the operative factors influencing the extraction efficiency, including extraction time, extraction temperature and ionic strength. The other parameters such as type of fiber coating, pH and derivatization conditions were also evaluated. SPME was finally carried out in headspace mode at 80°C for 60min with the presence of 3.00g Na2SO4, using a home-made 44μm PDMS fiber. Wide linear ranges and low limits of detection (0.06-1.24ng L(-1)) were obtained under the optimized conditions. The relative standard deviations (RSDs) and recoveries ranged from 0.5% to 12.3% and 85% to 110%, respectively. The proposed method was successfully applied to the analysis of the real surface water samples from the Pearl River Estuary.

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Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 100 μm(PDMS, for use with autosampler, needle size 23 ga
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 100 μm(PDMS, needle size 24 ga, for use with manual holder
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 100 μm(PDMS, for use with autosampler, needle size 24 ga
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, needle size 24 ga, StableFlex, for use with autosampler
Supelco
聚丙烯酸酯 (PA) 固相微萃取萃取头, df 85 μm(PA, for use with autosampler, needle size 23 ga
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, needle size 24 ga, for use with manual holder
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, needle size 23 ga, PDMS/DVB StableFlex, for use with autosampler
Supelco
聚丙烯酸酯 (PA) 固相微萃取萃取头, df 85 μm(PA, for use with autosampler, needle size 24 ga
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, needle size 24 ga, StableFlex, for use with manual holder
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, needle size 24 ga, for use with autosampler
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 100 μm(PDMS, for use with manual holder, needle size 23 ga
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), df 65 μm(PDMS/DVB, for use with autosampler, needle size 23 ga
Supelco
固相微萃取 StableFlex 萃取头组合套件, for use with manual holder
Supelco
固相微萃取 StableFlex 萃取头组合套件, needle size 23 ga, for use with autosampler
Supelco
Carbowax-聚乙二醇 (PEG) 固相微萃取萃取头, needle size 23 ga, df 60 μm(PEG, for use with autosampler
Supelco
SPME固相微萃取萃取头,二甲基硅氧烷/二乙烯基苯(PDMS/DVB), fused silica fiber, df 65 μm(PDMS/DVB, for use with manual holder, needle size 23 ga
Supelco
聚丙烯酸酯 (PA) 固相微萃取萃取头, df 85 μm(PA, for use with manual holder, needle size 24 ga
Supelco
SPME 纤维分类套件 4, for use with manual holder, size 24 ga
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 30 μm(PDMS, needle size 24 ga, for use with autosampler
Supelco
SPME-OC Fiber Assembly, Polydimethylsiloxane/Divinylbenzene (PDMS/DVB), df 75 μm(Coating thickness includes 65 μm coating + 10 μm OC (overcoating), needle size 23 ga, pkg of 3 ea, fiber L 1 cm
Supelco
Carbowax-聚乙二醇 (PEG) 固相微萃取萃取头, needle size 23 ga, df 60 μm(PEG, metal alloy fiber, for use with manual holder
Supelco
固相微萃取萃取头组合套件 1, for use with autosampler, needle size 24 ga
Supelco
固相微萃取便携式现场采样器, coating CAR/PDMS
Supelco
固相微萃取便携式现场采样器, coating PDMS
Supelco
固相微萃取便携式现场采样器, coating PDMS/DVB
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 7 μm(PDMS, needle size 23 ga, for use with autosampler
Supelco
固相微萃取取样操作平台, for use with 15 mL vials
Supelco
SPME 纤维组件聚二甲基硅氧烷 (PDMS), df 30 μm(PDMS, needle size 24 ga, for use with manual holder
Supelco
固相微萃取萃取头组合套件 1, for use with manual holder, needle size 24 ga
Supelco
固相微萃取 StableFlex 萃取头组合套件, needle size 24 ga, for use with autosampler