- Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Human molecular genetics (2016-07-19)
Joanne M Kingsbury, Nachiketha Shamaprasad, R Blake Billmyre, Joseph Heitman, Maria E Cardenas
PMID27427385
摘要
A major advance in understanding the progression and prognostic outcome of certain cancers, such as low-grade gliomas, acute myeloid leukaemia, and chondrosarcomas, has been the identification of early-occurring mutations in the NADP
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