- One-pot synthesis of 2,3-dihydro-pyrrolopyridinones using in situ generated formimines.
One-pot synthesis of 2,3-dihydro-pyrrolopyridinones using in situ generated formimines.
Organic letters (2006-12-01)
Geoffrey Deguest, Alice Devineau, Laurent Bischoff, Corinne Fruit, Francis Marsais
PMID17134298
摘要
A novel one-pot methodology is described for the synthesis of functionalized pyrrolopyridinones using in situ generated formimines and an ortho-lithiated pyridinecarboxamide species. Depending on the reaction conditions, this procedure allows versatile access to aminomethylated pyridinecarboxamides, 2,3-dihydro-pyrrolopyridinones, or 1,1-dialkylated 2,3-dihydro-pyrrolopyridinone derivatives. [reaction: see text]
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