- Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
European journal of medicinal chemistry (2005-06-01)
Patrick Angibaud, Janine Arts, Kristof Van Emelen, Virginie Poncelet, Isabelle Pilatte, Bruno Roux, Sven Van Brandt, Marc Verdonck, Hans De Winter, Peter Ten Holte, Ann Marien, Wim Floren, Boudewijn Janssens, Jacky Van Dun, An Aerts, Jacky Van Gompel, Sandrine Gaurrand, Laurence Queguiner, Jean-Michel Argoullon, Luc Van Hijfte, Eddy Freyne, Michel Janicot
PMID15922843
摘要
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
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