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Merck
  • Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater.

Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater.

Chemosphere (2015-04-26)
Laura Ferrando-Climent, Carles Cruz-Morató, Ernest Marco-Urrea, Teresa Vicent, Montserrat Sarrà, Sara Rodriguez-Mozaz, Damià Barceló
摘要

This work presents a study about the elimination of anticancer drugs, a group of pollutants considered recalcitrant during conventional activated sludge wastewater treatment, using a biological treatment based on the fungus Trametes versicolor. A 10-L fluidized bed bioreactor inoculated with this fungus was set up in order to evaluate the removal of 10 selected anticancer drugs in real hospital wastewater. Almost all the tested anticancer drugs were completely removed from the wastewater at the end of the batch experiment (8 days) with the exception of Ifosfamide and Tamoxifen. These two recalcitrant compounds, together with Cyclophosphamide, were selected for further studies to test their degradability by T. versicolor under optimal growth conditions. Cyclophosphamide and Ifosfamide were inalterable during batch experiments both at high and low concentration, whereas Tamoxifen exhibited a decrease in its concentration along the treatment. Two positional isomers of a hydroxylated form of Tamoxifen were identified during this experiment using a high resolution mass spectrometry based on ultra-high performance chromatography coupled to an Orbitrap detector (LTQ-Velos Orbitrap). Finally the identified transformation products of Tamoxifen were monitored in the bioreactor run with real hospital wastewater.

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Sigma-Aldrich
乙腈, anhydrous, 99.8%
SAFC
甲氨蝶呤
Sigma-Aldrich
依托泊苷, synthetic, 95.0-105.0%, powder
Sigma-Aldrich
乙腈 溶液, contains 0.1 % (v/v) trifluoroacetic acid, suitable for HPLC
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乙腈, electronic grade, 99.999% trace metals basis
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他莫昔芬 柠檬酸盐, ≥99%
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甲氨蝶呤, meets USP testing specifications
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硫唑嘌呤, ≥98%
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异环磷酰胺, ≥98%