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Hepatoprotective pyrrole derivatives of Lycium chinense fruits.

Bioorganic & medicinal chemistry letters (2002-12-07)
Young-Won Chin, Song-Won Lim, Seok-Ho Kim, Dong-Yun Shin, Young-Ger Suh, Yang-Bae Kim, Young Choong Kim, Jinwoong Kim
摘要

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively).

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Sigma-Aldrich
4-碘丁酸甲酯, 95%