跳转至内容

A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.

A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.

Organic letters (2014-06-17)

Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li

摘要

A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.

材料

货号

品牌

产品描述

Sigma-Aldrich

N,N-二甲基甲酰胺, ACS reagent, ≥99.8%

Sigma-Aldrich

N,N-二甲基甲酰胺, suitable for HPLC, ≥99.9%

Sigma-Aldrich

N,N-二甲基甲酰胺, anhydrous, 99.8%

Sigma-Aldrich

N,N-二甲基甲酰胺, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

Sigma-Aldrich

N,N-二甲基甲酰胺, ReagentPlus^®, ≥99%

Sigma-Aldrich

N,N-二甲基甲酰胺, for molecular biology, ≥99%

Sigma-Aldrich

N,N-二甲基甲酰胺, biotech. grade, ≥99.9%

Sigma-Aldrich

铜, powder, 99.999% trace metals basis

Sigma-Aldrich

铜, foil, thickness 0.25 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, powder, <425 μm, 99.5% trace metals basis

Sigma-Aldrich

铜, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

铜, powder (spheroidal), 10-25 μm, 98%

Sigma-Aldrich

铜, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

铜, powder, <75 μm, 99%

Sigma-Aldrich

铜, wire, diam. 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

铜, powder (dendritic), <45 μm, 99.7% trace metals basis

Sigma-Aldrich

铜, foil, ≥99.8% (complexometric)

Sigma-Aldrich

铜, turnings, purum p.a., ≥99.0%

Sigma-Aldrich

铜, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, wire, diam. 0.64 mm, 99.995% trace metals basis

Supelco

N,N-二甲基甲酰胺, analytical standard

Sigma-Aldrich

铜, beads, 2-8 mm, 99.9995% trace metals basis

Sigma-Aldrich

铜, foil, thickness 1.0 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, shot, −3-+14 mesh, 99%

铜, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

铜, rod, 100mm, diameter 9.5mm, hard, 99.9%

Sigma-Aldrich

铜, wire, diam. 2.0 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, ACS reagent, granular, 10-40 mesh, ≥99.90%