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Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Gastroenterology (2014-01-07)

Yatrik M Shah, Liwei Xie

摘要

Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is a transcription factor that is highly active in hypoxic cells. The first HIF target gene characterized was EPO, which encodes erythropoietin-a glycoprotein hormone that controls erythropoiesis. In the past decade, there have been fundamental advances in our understanding of how hypoxia regulates iron levels to support erythropoiesis and maintain systemic iron homeostasis. We review the cell type-specific effects of hypoxia and HIFs in adaptive response to changes in oxygen and iron availability as well as potential uses of HIF modulators for patients with iron-related disorders.

材料

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产品描述

Sigma-Aldrich

铁, ≥99%, reduced, powder (fine)

Sigma-Aldrich

羰基铁, ≥97% Fe basis

Sigma-Aldrich

铁, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

Sigma-Aldrich

铁, granular, 10-40 mesh, >99.99% trace metals basis

Sigma-Aldrich

铁, foil, thickness 0.1 mm, ≥99.9% trace metals basis

Sigma-Aldrich

铁, chips, 99.98% trace metals basis

Sigma-Aldrich

铁, wire, diam. 1.0 mm, ≥99.9% trace metals basis

铁, foil, 100x100mm, thickness 0.25mm, hard, 99.5%

Sigma-Aldrich

铁, foil, thickness 0.25 mm, ≥99.99% trace metals basis

铁, foil, 300x300mm, thickness 0.1mm, hard, 99.5%

铁, tube, 200mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

铁, foil, 100x100mm, thickness 0.125mm, as rolled, 99.99+%

铁, rod, 200mm, diameter 25mm, as drawn, 98+%

铁, rod, 100mm, diameter 100mm, as drawn, armcO« soft ingot 99.8%

铁, foil, 100x100mm, thickness 1.0mm, as rolled, 99.5%

铁, rod, 100mm, diameter 2.0mm, as drawn, 99.95%

铁, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%

铁, foil, 150x150mm, thickness 1.5mm, as rolled, 99.5%

铁, foil, 25x25mm, thickness 0.9mm, as rolled, 99.5%

铁, rod, 150mm, diameter 6.0mm, as drawn, 99.99+%

铁, tube, 200mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

铁, foil, 100x100mm, thickness 0.5mm, hard, 99.5%

铁, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%

铁, rod, 200mm, diameter 9.5mm, as drawn, soft ingot 99.8+%

铁, rod, 500mm, diameter 4.8mm, as drawn, 98+%

铁, foil, 50x50mm, thickness 0.1mm, hard, 99.5%

铁, foil, 25x25mm, thickness 0.5mm, hard, 99.5%

铁, rod, 100mm, diameter 4.8mm, as drawn, 98+%

铁, foil, 300x300mm, thickness 0.125mm, hard, 99.5%

铁, foil, 50x50mm, thickness 0.15mm, hard, 99.5%