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Merck
  • Recent insights in the removal of Klebseilla pathogenicity factors for the industrial production of 2,3-butanediol.

Recent insights in the removal of Klebseilla pathogenicity factors for the industrial production of 2,3-butanediol.

Journal of microbiology and biotechnology (2013-06-04)
Anupama Shrivastav, Jinwon Lee, Hae-Yeong Kim, Young-Rok Kim
摘要

2,3-Butanediol (2,3-BDO) has immense industrial applications. Recently, microbial fermentation has emerged as an alternative way to produce this industrially important chemical. Although 2,3-BDO is produced by several microorganisms, the Klebsiella genera has an excellent production compared with other 2,3-BDO-producing microorganisms. In order to produce 2,3- BDO on a large scale, the challenges of removing pathogenic factors from Klebsiella pneumoniae need to be addressed. K. pneumoniae produces a number of virulence factors that contribute to its pathogenesis, including lipopolysaccharides, capsules, fimbrial adhesins, etc. Removal of these pathogenic factors from 2,3-BDO-producing Klebsiella strains will result in avirulent strains for the safe, economic, and efficient production of 2,3-BDO. In this review, we summarize the current trends in 2,3-BDO production using K. pneumoniae and insights into the removal of its virulence factors for industrial applications.

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Sigma-Aldrich
2,3-丁二醇, 98%
Supelco
2,3-丁二醇, analytical standard, mixture of racemic and meso forms