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Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

摘要

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

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铂, gauze, 52 mesh, 99.9% trace metals basis

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铂, wire, diam. 0.5 mm, 99.9% trace metals basis

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铂, nanopowder, <50 nm particle size (TEM)

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铂黑, fuel cell grade, ≥99.9% trace metals basis

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铂, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

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铂, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

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铂黑, low bulk density, ≥99.9% trace metals basis

铂, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

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铂, foil, thickness 0.25 mm, 99.99% trace metals basis

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铂, foil, thickness 1.0 mm, 99.99% trace metals basis

铂, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

铂, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

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铂, powder (coarse), 99.99% trace metals basis

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铂, wire, diam. 0.25 mm, thermocouple grade

铂, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

铂, rod, 200mm, diameter 1.0mm, 99.95%