- Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.
Bioorganic & medicinal chemistry letters (2005-01-25)
Ronald Palin, David R Barn, John K Clark, Jean E Cottney, Phillip M Cowley, Marc Crockatt, Louise Evans, Helen Feilden, Richard R Goodwin, Frank Griekspoor, Simon J A Grove, Andrea K Houghton, Philip S Jones, Richard J Morphy, Alasdair R C Smith, Hardy Sundaram, David Vrolijk, Mark A Weston, Grant Wishart, Paul Wren
PMID15664818
摘要
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
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