Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.

Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.

Nucleic acids research (1983-11-25)

B C Froehler, M D Matteucci

摘要

Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.