Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy.

Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy.

Chemical communications (Cambridge, England) (2012-01-06)

Agustín Díaz, Vipin Saxena, Julissa González, Amanda David, Barbara Casañas, Carrie Carpenter, James D Batteas, Jorge L Colón, Abraham Clearfield, M Delwar Hussain

PMID22218458

摘要

Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.