- Copper-catalyzed synthesis of quinazolines in water starting from o-bromobenzylbromides and benzamidines.
Copper-catalyzed synthesis of quinazolines in water starting from o-bromobenzylbromides and benzamidines.
Chemistry (Weinheim an der Bergstrasse, Germany) (2012-06-26)
Chandi C Malakar, Alevtina Baskakova, Jürgen Conrad, Uwe Beifuss
PMID22730204
摘要
Water makes it possible: The Cu(2)O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs(2)CO(3) as the base and N,N'-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme).