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Merck
  • Supramolecular dynamics of thalidomide and its derivatives in water-sediment system.

Supramolecular dynamics of thalidomide and its derivatives in water-sediment system.

Chirality (2009-07-21)
Imran Ali, Vinod K Gupta, Hassan Y Aboul-Enein
摘要

The contamination of drug residues, including chiral ones, is not acceptable in earth's ecosystem. The dynamicity of enantiomers of thalidomide and its derivatives (3-methyl thalidomide, 3-ethyl thalidomide, and 3-butyl thalidomide) was ascertained at supramolecular level in water-sediment system using solid phase extraction (SPE) and stereoselective HPLC. Enantiomeric separation of these drugs was carried out on Ceramosphere RU-2 (25 cm x 0.46 cm, particle size 50 microm) chiral column using pure ethanol (1.0 ml/min) as eluent at 230 nm detection. Retention times, capacity, separation, and resolution factors of the enantiomers of these drugs were in the range of 20.0-36.0, 2.08-3.93, 1.35-1.57, and 1.0-2.0 min, respectively. Percentage recoveries of the enantiomers in SPE were in the range of 90.0 to 95.0 in water-sediment system. Langmuir and Freundlich model were best fitted for dynamic equilibrium concentrations at different experimental parameters. Thalidomide and its derivatives follow first-order kinetics at dynamic equilibrium. The rate constants of chiral interconversions were 0.390 and 0.385 days(-1) for S- and R-enantiomers, respectively. The uptake of thalidomide by sediment is quite good and of endothermic nature indicating good self-purification capacity of the nature for such toxic species.

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Sigma-Aldrich
弗洛里西®, 100-200 mesh
Supelco
Florisil® 色谱吸附剂, 60-100 mesh
Supelco
弗洛里西®, PR grade, 60-100 mesh, coarse powder
Supelco
弗洛里西®, 100-200 mesh, fine powder
Supelco
Florisil®, for the determination of hydrocarbon acc. to ISO 9377-2
Supelco
弗洛里西®, <200 mesh, fine powder
Supelco
过弗罗里 ® PR, PR grade (analysis acc. to FDA)
Supelco
色谱用 Florisil ® 吸附剂, 30-60 mesh