- Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters (2006-08-26)
Don R Finley, Michael G Bell, Anthony G Borel, William E Bloomquist, Marlene L Cohen, Mark L Heiman, Aidas Kriauciunas, Donald P Matthews, Tania Miles, David A Neel, Christopher J Rito, Daniel J Sall, Anthony J Shuker, Thomas W Stephens, Frank C Tinsley, Mark A Winter, Cynthia D Jesudason
PMID16931005
摘要
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
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