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  • Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization.

Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization.

The Journal of organic chemistry (2006-02-14)
Dun Zhang, Xuechao Xing, Gregory D Cuny
摘要

A method for the preparation of enantiomerically pure hydantoins from optically pure alpha-amino amides utilizing triphosgene is described. We also propose that the racemization observed with 1,1'-carbonyldiimidazole (CDI) for this type of reaction is due to the imidazole carbamate intermediates.

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三光气, reagent grade, 98%