跳转至内容
Merck
  • Modeling of prebiotic catalysis with adenylated polymeric templates: crystal structure studies and kinetic characterization of template-assisted phosphate ester hydrolysis.

Modeling of prebiotic catalysis with adenylated polymeric templates: crystal structure studies and kinetic characterization of template-assisted phosphate ester hydrolysis.

Chemistry (Weinheim an der Bergstrasse, Germany) (2003-03-05)
S G Srivatsan, Masood Parvez, Sandeep Verma
摘要

We have synthesized and characterized novel, copper-metalated, polymeric templates that contain adenine nucleobases. These promote hydrolysis of non-natural and natural phosphate ester substrates in a highly efficient and catalytic fashion. The crystal structure of the cooper-containing adenylated monomer reveals the formation of a polymeric array, through coordination to both N1 and N7 atoms. Possible implications of these studies for prebiotic catalysis, involving synergism between adenine and copper ions, are also discussed.

材料
货号
品牌
产品描述

Sigma-Aldrich
腺苷 2′:3′-循环磷酸钠盐 钠盐, ≥93%